Interactions can affect either medicine
NHS explains that esomeprazole may alter another medicine’s effect or be affected by it. Its review list includes digoxin, methotrexate, phenytoin, rifampicin, clopidogrel, warfarin, selected antifungals, HIV medicines and some medicines for anxiety or low mood. This is a review list, not an instruction to stop every listed medicine. [1]
St John’s wort is a specific herbal concern
NHS says not to take St John’s wort with esomeprazole because it may make esomeprazole work less well. It also states that information is insufficient to declare other herbal remedies safe with the drug. An unlisted supplement is not automatically a proven safe combination. [1]
Use the complete current list
Include prescribed treatments, nonprescription medicines, vitamins and herbal blends. A pharmacist can compare the actual formula and medicine leaflet rather than relying on a generic stomach-medicine label. Do not assume that changing the time of day resolves every interaction. [1][2]
Resolve the new addition before changing established care
Imagine someone taking clopidogrel plans to add over-the-counter Nexium. Bring that proposed addition to the pharmacist first. The useful result is an appropriate treatment plan, not independently skipping a prescribed medicine so the new product can be taken. [1]
| Current treatment | Proposed addition |
|---|---|
| Clopidogrel | Esomeprazole |
| Needed action | Pharmacist or prescriber interaction review |
Sources for this article
- Taking esomeprazole with other medicines and herbal supplements - NHS
Source consulted: 2026-09-20. This is a reference resource, not a claim that we conducted the studies or tested a product. - Dietary Supplements: What You Need to Know
Source consulted: 2026-09-20. This is a reference resource, not a claim that we conducted the studies or tested a product.