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    Ingredient guide · Ingredient reference

    Rosuvastatin interactions: review medicines, supplements and antacid timing

    Rosuvastatin has specific interaction considerations, including some cholesterol medicines, anti-infectives and anticoagulants. Aluminum/magnesium hydroxide antacids have a timing rule, and supplement safety cannot be inferred from a natural label.

    Read the evidence ↓

    Supplement Science Insights Editorial Team

    Published September 23, 2026

    Start with the exact medication list

    NHS highlights other cholesterol medicines such as fibrates, selected antibiotics, HIV or hepatitis C medicines, warfarin or clopidogrel, and ciclosporin among items requiring review. This is not a complete interaction list. The prescriber may adjust treatment or monitoring rather than banning an entire medicine category. [1]

    Antacid timing is product-specific

    MedlinePlus advises taking aluminum and magnesium hydroxide antacids at least two hours after rosuvastatin. That statement should not be casually generalized into a rule for every magnesium food or supplement. Show the pharmacist the exact antacid and supplement labels. [2]

    Be cautious about adding a second cholesterol product

    Red yeast rice can contain a substance identical to lovastatin and can share statin-like adverse effects and interactions. Adding it to rosuvastatin is not simply adding a harmless food extract. Review any cholesterol blend before use, including its full ingredient list. [3]

    Report important symptoms rather than treating them with another supplement

    Unexplained muscle pain or weakness, dark urine or signs of liver trouble warrant prompt medical advice. Imagine these begin after adding a new product: bring both packages and the timing to the clinician instead of assuming a vitamin will correct the problem. [2]

    Hypothetical example — check the medicine identity before assuming an equivalent supplement
    Label or questionMeaning
    Aluminum/magnesium hydroxide antacidAt least two hours after rosuvastatin
    Red yeast ricePotential additional statin-like exposure
    New muscle symptoms or dark urinePrompt clinical review
    Rosuvastatin interactions: review medicines, supplements and antacid timing — original article outline diagram
    Original editorial diagram of this article’s sections; no product photograph or clinical finding is depicted.

    Sources for this article

    1. Rosuvastatin - NHS
      Source consulted: 2026-09-20. This is a reference resource, not a claim that we conducted the studies or tested a product.
    2. Rosuvastatin: MedlinePlus Drug Information
      Source consulted: 2026-09-20. This is a reference resource, not a claim that we conducted the studies or tested a product.
    3. Cholesterol Management at a Glance | NCCIH
      Source consulted: 2026-09-20. This is a reference resource, not a claim that we conducted the studies or tested a product.