The exact medicine matters
The manufacturer lists medicines including rifampin, carbamazepine, phenytoin, oxcarbazepine, topiramate, griseofulvin, aprepitant and certain HIV or hepatitis C treatments. This is not a claim that every antibiotic or every medicine in a broad category has the same effect. Show the actual medicine name and dose to the prescriber. [1]
Herbal products count
St John’s wort is specifically listed. Include herbal mood products and all other supplements in the review, even when they were bought without a prescription. Tell healthcare professionals that the implant is in place before a new treatment is selected. [1]
A backup plan can extend beyond the last dose
The manufacturer says that if an interacting treatment is used while the implant remains in place, additional nonhormonal contraception should be used. It states that the effect can persist for up to 28 days after stopping the interacting medicine, requiring backup for that period. Obtain a plan for the particular treatment rather than stopping prescribed therapy on your own. [1]
Bring both treatment details to the same conversation
Imagine a new medicine is prescribed by a clinician who does not know about the implant. Before starting, disclose Nexplanon and ask whether backup or an alternative is needed. Record when backup should begin and end; the medicine’s last dose alone may not mark the end of the interaction. [1]
| Detail | Why it matters |
|---|---|
| Exact medicine or herb | Determines whether an interaction applies |
| Start and stop dates | Helps define backup duration |
Sources for this article
- Medicine Interactions with NEXPLANON® (etonogestrel implant) 68 mg Radiopaque
Source consulted: 2026-09-20. This is a reference resource, not a claim that we conducted the studies or tested a product.