Ingredient guide · Ingredient reference

Does NyQuil contain melatonin? Check the exact product

The US NyQuil Cold & Flu LiquiCaps ingredient list contains acetaminophen, dextromethorphan and doxylamine, not melatonin. Vicks also sells separate ZzzQuil PURE Zzzs supplements that do contain melatonin. Similar nighttime branding does not mean the same formula.

Read the evidence ↓

Supplement Science Insights Editorial Team

Published September 23, 2026

What the Cold & Flu LiquiCaps contain

The manufacturer lists acetaminophen for pain and fever, dextromethorphan as a cough suppressant and doxylamine as an antihistamine. This describes the named US Cold & Flu LiquiCaps product, not every NyQuil product or every country’s formulation. Check the Drug Facts on your own package. [1]

PURE Zzzs is a different product family

The inspected ZzzQuil PURE Zzzs Complete Sleep page lists melatonin alongside L-theanine, GABA, ashwagandha and magnesium. That combination should not be inferred from a NyQuil label, and the ingredient list is not proof that the blend is right for a particular sleep problem. [2][3]

Compare active ingredients rather than the bedtime wording

Imagine a person says they took the nighttime Vicks product. Ask for the exact name and label before discussing ingredients or adding another product. A cold medicine and a melatonin-containing supplement answer different questions; neither should be identified by package color alone. [1][2]

Hypothetical example — identify two similarly branded preparations
Named productIngredient distinction
NyQuil Cold & Flu LiquiCapsAcetaminophen, dextromethorphan, doxylamine
PURE Zzzs Complete SleepMelatonin-containing supplement blend
Does NyQuil contain melatonin? Check the exact product — original article outline diagram
Original editorial diagram of this article’s sections; no product photograph or clinical finding is depicted.

Sources for this article

  1. NyQuil Cold & Flu Nighttime Relief LiquiCaps | Vicks
    Source consulted: 2026-09-20. This is a reference resource, not a claim that we conducted the studies or tested a product.
  2. PURE Zzzs 10mg Melatonin‡ Complete Sleep Capsules | ZzzQuil
    Source consulted: 2026-09-20. This is a reference resource, not a claim that we conducted the studies or tested a product.
  3. Dietary Supplements: What You Need to Know
    Source consulted: 2026-09-20. This is a reference resource, not a claim that we conducted the studies or tested a product.