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Pregnancy iodine and child cognition: a trial with substantial follow-up loss

Supplementation did not significantly improve measured childhood cognitive outcomes in this mildly deficient population.

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Supplement Science Insights Editorial Team

Published September 23, 2026

The study and its comparison

A trial in India and Thailand randomized 832 pregnant women to iodine 200 micrograms daily or placebo until delivery. Children were assessed at ages five to six years. [1]

Verbal and performance IQ analyses included 313 children; executive-function analysis included 315. None of these primary comparisons showed a significant benefit. [1]

What the finding establishes

The large reduction from maternal enrollment to child assessment limits interpretation. The study does not answer treatment of severe iodine deficiency or justify stopping prescribed prenatal care. Funding included Swiss National Science Foundation, Nestle Foundation and university support; full conflicts were not established from the record. [1]

A hypothetical distinction

Imagine many enrolled families do not contribute the final child test. The initial enrollment is not the outcome-analysis denominator.

Interpretation checklist — Pregnancy iodine and child cognition
DetailInterpretation
Measured outcomeKeep the endpoint specific
Study preparationNot every retail product
Remaining uncertaintyNot resolved by a mechanism
Pregnancy iodine and child cognition: a trial with substantial follow-up loss — original article outline diagram
Original editorial diagram of this article’s sections; no product photograph or clinical finding is depicted.

Sources for this article

  1. Effect of iodine supplementation in pregnant women on child neurodevelopment: a randomised, double-blind, placebo-controlled trial.
    Source consulted: 2026-09-19. This is a reference resource, not a claim that we conducted the studies or tested a product.