SUPPLEMENT SCIENCEInsights
Search

Search Insights

Try choline, nano-curcumin or probiotics.

    Ingredient guide · Ingredient reference

    What are the negative effects of magic mushrooms?

    Psilocybin mushrooms can cause nausea, headache, dizziness, anxiety, panic, confusion and increased heart rate or blood pressure. Less common but important concerns include persistent perceptual or psychiatric symptoms, injuries and poisoning from other ingredients or misidentified species. Risk varies by person and exposure.

    Read the evidence ↓

    Supplement Science Insights Editorial Team

    Published September 23, 2026

    Acute physical and psychological effects can overlap

    A person may experience stomach upset and cardiovascular changes while also feeling frightened or disoriented. Calling an event a bad trip does not establish that it can be safely managed without medical advice. [1][2]

    Some effects can continue after the main experience

    Poor sleep, fatigue and ongoing distress can follow exposure. NIDA also describes uncommon persistent perceptual disturbances and psychiatric complications, with limited evidence for precise individual risk estimates. [1][2]

    The actual product and setting matter

    Unregulated processed products, other drugs, pre-existing conditions and dangerous surroundings change the risk. A poisonous look-alike can cause organ damage rather than only a psychedelic effect. Clinical screening results cannot simply be generalized to these circumstances. [3][2]

    Act on severe symptoms

    Imagine someone develops convulsions, chest symptoms, difficulty breathing or loss of consciousness. Seek emergency care. For uncertain exposure or unwanted effects, Poison Control can advise; keep the packaging and tell clinicians about other substances. [3][4]

    Hypothetical example — recognize hypothetical adverse patterns
    PatternConcern
    Nausea and panicAcute adverse response
    Ongoing visual changesAssessment for persistent effects
    Unknown speciesPotential serious poisoning
    Seizure or breathing difficultyEmergency
    What are the negative effects of magic mushrooms? — original article outline diagram
    Original editorial diagram of this article’s sections; no product photograph or clinical finding is depicted.

    Sources for this article

    1. Psilocybin for Mental Health and Addiction: What You Need To Know | NCCIH
      Source consulted: 2026-09-21. This is a reference resource, not a claim that we conducted the studies or tested a product.
    2. Psychedelic and Dissociative Drugs | National Institute on Drug Abuse (NIDA)
      Source consulted: 2026-09-21. This is a reference resource, not a claim that we conducted the studies or tested a product.
    3. Magic Mushrooms (Psilocybin) Safety | California Poison Control System
      Source consulted: 2026-09-21. This is a reference resource, not a claim that we conducted the studies or tested a product.
    4. Poisoning first aid: MedlinePlus Medical Encyclopedia
      Source consulted: 2026-09-21. This is a reference resource, not a claim that we conducted the studies or tested a product.