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    Ingredient guide · Ingredient reference

    Does melatonin raise or lower blood pressure?

    Melatonin does not have one predictable blood-pressure effect for everyone. Some research finds small reductions in selected measurements, while interactions and individual responses can differ. It should not replace blood-pressure treatment or be added as a pressure-lowering supplement without reviewing current medicines.

    Read the evidence ↓

    Supplement Science Insights Editorial Team

    Published September 23, 2026

    Daytime and nighttime results are different questions

    A 2024 review of randomized trials reported a small pooled reduction in daytime diastolic pressure, but no significant overall systolic effect. The review examined several body-composition and blood-pressure outcomes; its total participant count does not mean every outcome was measured in every participant. [1]

    An average result does not predict a personal response

    Formulation, timing, baseline blood pressure and concurrent medicines matter. The review called for larger and longer studies. A statistically detectable average change is not an established treatment plan for hypertension or evidence that every melatonin product lowers pressure. [1]

    Medication review is essential

    NHS specifically lists blood-pressure medicines among drugs to discuss before taking melatonin. Do not assume an apparent supplement-related reading means the prescribed medicine should be stopped. Review the product and a properly recorded pattern of readings with the prescriber or pharmacist. [2]

    Avoid adjusting two treatments from one reading

    Imagine a person sees a higher reading after starting melatonin. Record when it occurred, how it was measured and all medicines taken, then seek advice about the pattern. One observation cannot establish whether melatonin, measurement conditions or another factor caused it. [1][2]

    Hypothetical example — interpret a pressure claim
    DetailWhy it matters
    Systolic versus diastolicDifferent endpoints
    Day versus nightDifferent measurement windows
    Average trial effectNot an individual guarantee
    Other medicinesPossible interaction
    Does melatonin raise or lower blood pressure? — original article outline diagram
    Original editorial diagram of this article’s sections; no product photograph or clinical finding is depicted.

    Sources for this article

    1. Effect of melatonin supplementation on body composition and blood pressure in adults: A systematic review and Dose-Response meta-analysis of randomized controlled trial.
      Source consulted: 2026-09-21. This is a reference resource, not a claim that we conducted the studies or tested a product.
    2. Taking melatonin with other medicines and herbal supplements - NHS
      Source consulted: 2026-09-21. This is a reference resource, not a claim that we conducted the studies or tested a product.