Botanical guide · Ingredient reference

Cordyceps Cs-4 pilot: exercise thresholds and maximum capacity differed

An older-adult pilot reported changes in exercise thresholds, while maximal oxygen consumption remained unchanged.

Read the evidence ↓

Supplement Science Insights Editorial Team

Published September 23, 2026

What was tested

Twenty healthy adults aged 50–75 entered a double-blind placebo-controlled trial lasting 12 weeks. Researchers tested cycling performance before and after supplementation with the Cs-4 preparation. [1]

Metabolic and ventilatory thresholds increased within the active group, while similar changes were not reported for placebo. Neither group improved maximal oxygen consumption. The abstract does not provide a clear treatment-by-time comparison for each threshold. [1]

How far the result applies

A significant change in one group and no significant change in another does not alone establish a significant difference between groups. The small pilot therefore supports further investigation more strongly than a general stamina promise. Funding and conflicts were not established from the abstract. [1]

A hypothetical reading of the evidence

Imagine a cyclist reaches a threshold later but has the same maximum oxygen uptake. The two measurements need not tell the same story.

Interpretation checklist — Cordyceps Cs-4 pilot
DetailInterpretation
Study resultLimited to its measured outcomes
Other preparationEquivalence not established
Broader claimNeeds separate evidence
Cordyceps Cs-4 pilot: exercise thresholds and maximum capacity differed — original article outline diagram
Original editorial diagram of this article’s sections; no product photograph or clinical finding is depicted.

Sources for this article

  1. Effect of Cs-4 (Cordyceps sinensis) on exercise performance in healthy older subjects: a double-blind, placebo-controlled trial - PubMed
    Source consulted: 2026-09-19. This is a reference resource, not a claim that we conducted the studies or tested a product.