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Reishi in metabolic syndrome: a controlled trial found no benefit

A 16-week trial did not support reishi for the cardiovascular risk factors it tested in adults with diabetes and metabolic syndrome.

Read the evidence ↓

Supplement Science Insights Editorial Team

Published September 23, 2026

What was tested

Researchers randomized 84 participants to reishi, reishi with Cordyceps sinensis, or placebo. The active regimens supplied 3 grams of reishi daily; their results were pooled for analysis. [1]

Neither glycated hemoglobin nor fasting glucose improved relative to placebo. Secondary outcomes were also negative. This matters because the primary outcomes were defined measures, not a general impression of better health. [1]

How far the result applies

Pooling the two active regimens limits conclusions about their individual differences. The study concerns its preparations and population; it cannot establish the effect of every mushroom product. It also does not justify replacing diabetes treatment. Funding and conflicts were not established from the retrieved abstract. [1]

A hypothetical reading of the evidence

Imagine an advertisement promises better glucose control. A laboratory mechanism would not override a negative controlled clinical result for the tested regimen.

Interpretation checklist — Reishi in metabolic syndrome
DetailInterpretation
Study resultLimited to its measured outcomes
Other preparationEquivalence not established
Broader claimNeeds separate evidence
Reishi in metabolic syndrome: a controlled trial found no benefit — original article outline diagram
Original editorial diagram of this article’s sections; no product photograph or clinical finding is depicted.

Sources for this article

  1. A double-blind, randomised, placebo-controlled trial of Ganoderma lucidum for the treatment of cardiovascular risk factors of metabolic syndrome - PubMed
    Source consulted: 2026-09-19. This is a reference resource, not a claim that we conducted the studies or tested a product.