Botanical guide · Ingredient reference

Reishi crossover study: blood pressure did not change

A controlled crossover trial found no blood-pressure reduction, even though some metabolic measurements suggested possible effects.

Read the evidence ↓

Supplement Science Insights Editorial Team

Published September 23, 2026

What was tested

Twenty-six people with borderline elevated blood pressure or cholesterol entered a study of 1.44 grams daily of Lingzhi versus matching placebo. Each treatment period lasted 12 weeks; 23 participants were evaluable. [1]

Blood pressure and body mass index did not change. Insulin and an insulin-resistance estimate were lower after Lingzhi, but carry-over effects prevented complete analysis of triglyceride and HDL results. [1]

How far the result applies

Carry-over means an earlier treatment can influence a later period, complicating the comparison. These mixed findings should not be compressed into a claim that reishi lowers blood pressure. The small study does not establish cardiovascular-event prevention. Funding and conflicts were not established from the abstract. [1]

A hypothetical reading of the evidence

Imagine an effect persists into the next period. The later measurement may no longer represent that period’s treatment alone.

Interpretation checklist — Reishi crossover study
DetailInterpretation
Study resultLimited to its measured outcomes
Other preparationEquivalence not established
Broader claimNeeds separate evidence
Reishi crossover study: blood pressure did not change — original article outline diagram
Original editorial diagram of this article’s sections; no product photograph or clinical finding is depicted.

Sources for this article

  1. Study of potential cardioprotective effects of Ganoderma lucidum (Lingzhi): results of a controlled human intervention trial - PubMed
    Source consulted: 2026-09-19. This is a reference resource, not a claim that we conducted the studies or tested a product.